NOTE: This is NOT a complete list. so, it’s very important to provide ICS with a complete list of medications that you are taking, including:

  • Prescriptions
  • Over the counter medications
  • Supplements.

You can provide this list when filling out the ICS INTAKE-FORM

When metabolized by the liver, Ibogaine gets converted into 
it's metabolite 12-hydroxyibogamine (noribogaine). Metabolism of ibogaine occurs mainly through two (or more) enzymes catalyzed by cytochrome P4502D6 (CYP2D6). The CYP2D6 enzymes are used to metabolize many medications, certain supplements, and as well foods. When combined with ibogaine the following medications listed can prolong QT intervals and cause cardiac arrhythmias:

Cytochrome P4502D6 (CYP2D6) blockers/competitors

Anti-arrhythmic drugs:

  • Metoprolol
  • Propafenone
  • Timolol maleate

Antidepressant drugs:

  • Amitriptyline (Elavil)
  • Citalopram (Celexa)
  • Clomipramine
  • Desipramine
  • Duloxetine (Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane)
  • Escitalopram (Lexapro)
  • Imipramine (Tofranil)
  • Paroxetine (Paxil)
  • Venlafaxine (Effexor)


  • Aripiprazole (Abilify, Aripiprex)
  • Haloperidol (Haldol)
  • Pimozide (Orap)
  • Risperidone (Risperdal)
  • Thioridazine (Mellaril, Sonapax, Thioril)

Drugs that prolong QT intervals (not a good combination with ibogaine treatment):

  • Amiodarone
  • Azithromycin (Zithromax)
  • Bepridil (Vascor)
  • Chloroquine (Aralen)
  • Chlorpromazine (Thorazine, Largactil)
  • Clarithromycin (Biaxin)
  • Disopyramide (Norpace)
  • Dofetilide (Tikosyn)
  • Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar)
  • Erythromycin (Isotrexin)
  • Flecainide acetate (Tambocor, Almarytm, Apocard, Ecrinal, Flécaine)
  • Halofantrine (Halfan)
  • Moxifloxacin (Avelox, Avalox, Avelon, Vigamox, Moxeza)
  • Pentamidine (NebuPent)
  • Procainamide (Pronestyl, Procan, Procanbid)
  • Quinidine (Quinaglute)
  • Sevoflurane (Ulane)

Other common medications that compete with the ibogaine molecule:

  • Codeine (3-methylmorphine)
  • Dextromethorphan (DXM, DM)
  • Methadone (Methadose)
  • Mexiletine (Mexitil)
  • Ondansetron (Zofran)
  • Tamoxifen (Nolvadex, Istubal, Valodex)
  • Tramadol (Ultram, Ralivia, Tramal)

Foods such as grapefruit juice, and a variety of other supplements and over-the-counter medications such as Prilosec (Omeprazole), various gastric drugs, anti-fungal medications, HIV treatment drugs, and some antihistamines, can all contribute to significantly prolonging QT intervals and cause problems when still circulating within the body at
time of ibogaine treatment.